CovidV1, Main, Exploration, bibRecord, 000B64

Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy

Identifieur interne : 000B64 ( Main/Exploration ); précédent : 000B63; suivant : 000B65

Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy

Auteurs : Yoko Kita ; Satomi Hashimoto ; Toshihiro Nakajima ; Hitoshi Nakatani ; Shiho Nishimatsu ; Yasuko Nishida ; Noriko Kanamaru ; Yasuhumi Kaneda ; Yasushi Takamori ; David Mcmurray [États-Unis] ; Esterlina V. Tan [Philippines] ; Marjorie L. Cang [Philippines] ; Paul Saunderson [Philippines] ; E. C. Dela Cruz [Philippines] ; Masaji Okada

Source :

Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2012.

RBID : PMC:3891708

Abstract

Purpose: Multi-drug resistant tuberculosis (MDR-TB) and extremely drug resistant (XDR) TB are big problems in the world. We have developed novel TB therapeutic vaccines, HVJ-Envelope/HSP65 + IL-12 DNA vaccine (HSP65-vaccine), granulysin vaccine and killer specific secretory protein of 37kDa (Ksp37) vaccine.

Methods and Results: HSP65 vaccine showed strong therapeutic effect against both MDR-TB and XDR-TB in mice. Intradermal immunization of HSP65-vaccine showed stronger therapeutic effect against TB than intramuscular or subcutaneous immunization. Furthermore, the synergistic therapeutic effect was observed when the vaccine was administrated in combination with Isoniazid (INH), which is a first line drug for chemotherapy. The combination of types of vaccines (HSP65- and granulysin- vaccines) also showed synergistic therapeutic effect. In the monkey model, granulysin-vaccine prolonged the survival period after the infection of TB and long-term survival was observed in vaccine-treated group. We examined the potential of two kinds of novel DNA vaccines (Ksp37-vaccine and granulysin-vaccine). Both vaccines augmented in vivo differentiation of CTL against TB. We measured the amount of Ksp37 protein in human serum and revealed that the level of Ksp37 protein of patients with tuberculosis was lower than that of healthy volunteers. Therefore, we established Ksp37 transgenic mice as well as granulysin transgenic mice to elucidate the function of those proteins. Both transgenic mice were resistant to TB infection.

Conclusion: These data indicate the potential of combinational therapy; the combination of two DNA vaccines or combination of DNA vaccine with antibiotic drug. Thus, it will provide a novel strategy for the treatment of MDR-TB.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891708

DOI: 10.4161/hv.23230
PubMed: 23249609
PubMed Central: 3891708

Affiliations:

Le document en format XML

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<author><name sortKey="Kaneda, Yasuhumi" sort="Kaneda, Yasuhumi" uniqKey="Kaneda Y" first="Yasuhumi" last="Kaneda">Yasuhumi Kaneda</name>
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<author><name sortKey="Cang, Marjorie L" sort="Cang, Marjorie L" uniqKey="Cang M" first="Marjorie L." last="Cang">Marjorie L. Cang</name>
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<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy</title>
<author><name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
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<author><name sortKey="Nakajima, Toshihiro" sort="Nakajima, Toshihiro" uniqKey="Nakajima T" first="Toshihiro" last="Nakajima">Toshihiro Nakajima</name>
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<wicri:noCountry code="subfield">Ikeda</wicri:noCountry>
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<wicri:noCountry code="subfield">Sakai Japan</wicri:noCountry>
</affiliation>
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<author><name sortKey="Nishimatsu, Shiho" sort="Nishimatsu, Shiho" uniqKey="Nishimatsu S" first="Shiho" last="Nishimatsu">Shiho Nishimatsu</name>
<affiliation><nlm:aff id="A1">Clinical Research Center; National Hospital Organization Kinki-chuo Chest Medical Center; Kitaku, Sakai Japan</nlm:aff>
<wicri:noCountry code="subfield">Sakai Japan</wicri:noCountry>
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<author><name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
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<wicri:noCountry code="subfield">Sakai Japan</wicri:noCountry>
</affiliation>
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<author><name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<affiliation><nlm:aff id="A1">Clinical Research Center; National Hospital Organization Kinki-chuo Chest Medical Center; Kitaku, Sakai Japan</nlm:aff>
<wicri:noCountry code="subfield">Sakai Japan</wicri:noCountry>
</affiliation>
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<author><name sortKey="Kaneda, Yasuhumi" sort="Kaneda, Yasuhumi" uniqKey="Kaneda Y" first="Yasuhumi" last="Kaneda">Yasuhumi Kaneda</name>
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<wicri:noCountry code="subfield">Osaka Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Takamori, Yasushi" sort="Takamori, Yasushi" uniqKey="Takamori Y" first="Yasushi" last="Takamori">Yasushi Takamori</name>
<affiliation><nlm:aff id="A4">Department of Periodontology; Tsurumi University School of Dental Medicine; Tsurumi, Tsurumiku Japan</nlm:aff>
<wicri:noCountry code="subfield">Tsurumiku Japan</wicri:noCountry>
</affiliation>
</author>
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<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Texas A&M University; System Health Center; College of Medicine; College Station</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tan, Esterlina V" sort="Tan, Esterlina V" uniqKey="Tan E" first="Esterlina V." last="Tan">Esterlina V. Tan</name>
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<country xml:lang="fr">Philippines</country>
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</affiliation>
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<author><name sortKey="Saunderson, Paul" sort="Saunderson, Paul" uniqKey="Saunderson P" first="Paul" last="Saunderson">Paul Saunderson</name>
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</affiliation>
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<author><name sortKey="Dela Cruz, E C" sort="Dela Cruz, E C" uniqKey="Dela Cruz E" first="E. C." last="Dela Cruz">E. C. Dela Cruz</name>
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</affiliation>
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<author><name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
<affiliation><nlm:aff id="A1">Clinical Research Center; National Hospital Organization Kinki-chuo Chest Medical Center; Kitaku, Sakai Japan</nlm:aff>
<wicri:noCountry code="subfield">Sakai Japan</wicri:noCountry>
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<series><title level="j">Human Vaccines & Immunotherapeutics</title>
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<front><div type="abstract" xml:lang="en"><p>Purpose: Multi-drug resistant tuberculosis (MDR-TB) and extremely drug resistant (XDR) TB are big problems in the world. We have developed novel TB therapeutic vaccines, HVJ-Envelope/HSP65 + IL-12 DNA vaccine (HSP65-vaccine), granulysin vaccine and killer specific secretory protein of 37kDa (Ksp37) vaccine.
</p>
<p>Methods and Results: HSP65 vaccine showed strong therapeutic effect against both MDR-TB and XDR-TB in mice. Intradermal immunization of HSP65-vaccine showed stronger therapeutic effect against TB than intramuscular or subcutaneous immunization. Furthermore, the synergistic therapeutic effect was observed when the vaccine was administrated in combination with Isoniazid (INH), which is a first line drug for chemotherapy. The combination of types of vaccines (HSP65- and granulysin- vaccines) also showed synergistic therapeutic effect. In the monkey model, granulysin-vaccine prolonged the survival period after the infection of TB and long-term survival was observed in vaccine-treated group. We examined the potential of two kinds of novel DNA vaccines (Ksp37-vaccine and granulysin-vaccine). Both vaccines augmented in vivo differentiation of CTL against TB. We measured the amount of Ksp37 protein in human serum and revealed that the level of Ksp37 protein of patients with tuberculosis was lower than that of healthy volunteers. Therefore, we established Ksp37 transgenic mice as well as granulysin transgenic mice to elucidate the function of those proteins. Both transgenic mice were resistant to TB infection.</p>
<p>Conclusion: These data indicate the potential of combinational therapy; the combination of two DNA vaccines or combination of DNA vaccine with antibiotic drug. Thus, it will provide a novel strategy for the treatment of MDR-TB.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Philippines</li>
<li>États-Unis</li>
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<region><li>Texas</li>
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<tree><noCountry><name sortKey="Hashimoto, Satomi" sort="Hashimoto, Satomi" uniqKey="Hashimoto S" first="Satomi" last="Hashimoto">Satomi Hashimoto</name>
<name sortKey="Kanamaru, Noriko" sort="Kanamaru, Noriko" uniqKey="Kanamaru N" first="Noriko" last="Kanamaru">Noriko Kanamaru</name>
<name sortKey="Kaneda, Yasuhumi" sort="Kaneda, Yasuhumi" uniqKey="Kaneda Y" first="Yasuhumi" last="Kaneda">Yasuhumi Kaneda</name>
<name sortKey="Kita, Yoko" sort="Kita, Yoko" uniqKey="Kita Y" first="Yoko" last="Kita">Yoko Kita</name>
<name sortKey="Nakajima, Toshihiro" sort="Nakajima, Toshihiro" uniqKey="Nakajima T" first="Toshihiro" last="Nakajima">Toshihiro Nakajima</name>
<name sortKey="Nakatani, Hitoshi" sort="Nakatani, Hitoshi" uniqKey="Nakatani H" first="Hitoshi" last="Nakatani">Hitoshi Nakatani</name>
<name sortKey="Nishida, Yasuko" sort="Nishida, Yasuko" uniqKey="Nishida Y" first="Yasuko" last="Nishida">Yasuko Nishida</name>
<name sortKey="Nishimatsu, Shiho" sort="Nishimatsu, Shiho" uniqKey="Nishimatsu S" first="Shiho" last="Nishimatsu">Shiho Nishimatsu</name>
<name sortKey="Okada, Masaji" sort="Okada, Masaji" uniqKey="Okada M" first="Masaji" last="Okada">Masaji Okada</name>
<name sortKey="Takamori, Yasushi" sort="Takamori, Yasushi" uniqKey="Takamori Y" first="Yasushi" last="Takamori">Yasushi Takamori</name>
</noCountry>
<country name="États-Unis"><region name="Texas"><name sortKey="Mcmurray, David" sort="Mcmurray, David" uniqKey="Mcmurray D" first="David" last="Mcmurray">David Mcmurray</name>
</region>
</country>
<country name="Philippines"><noRegion><name sortKey="Tan, Esterlina V" sort="Tan, Esterlina V" uniqKey="Tan E" first="Esterlina V." last="Tan">Esterlina V. Tan</name>
</noRegion>
<name sortKey="Cang, Marjorie L" sort="Cang, Marjorie L" uniqKey="Cang M" first="Marjorie L." last="Cang">Marjorie L. Cang</name>
<name sortKey="Dela Cruz, E C" sort="Dela Cruz, E C" uniqKey="Dela Cruz E" first="E. C." last="Dela Cruz">E. C. Dela Cruz</name>
<name sortKey="Saunderson, Paul" sort="Saunderson, Paul" uniqKey="Saunderson P" first="Paul" last="Saunderson">Paul Saunderson</name>
</country>
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Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy

Novel therapeutic vaccines [(HSP65 + IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy

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Abstract

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